Table 3.

Correlation between biomarkers and ALS clinical parameters at baseline.

Biomarker/Ratios	Basal ALSFRS-R	Basal Weight
Aβ1-42	0.30 [0.12; 0.46] p = 0.001	−0.47 [−0.23; 0.14] p = 0.61
Phospho-tau	0.05 [−0.14; 0.23] p = 0.59	−0.21 [−0.38; −0.03] p = 0.02
Total tau	−0.15 [−0.33; 0.03] p = 0.09	−0.34 [−0.49; −0.17] p = 0.0001
IATI	0.32 [0.14; 0.47] p = 0.0004	0.24 [0.05; 0.40] p = 0.009
Ratio Aβ1-42/P-tau	0.09 [−0.09; 0.28] p = 0.29	0.14 [−0.04; 0.32] p = 0.12
Ratio p-Tau/total Tau	0.26 [0.08; 0.43] p = 0.004	0.36 [0.19; 0.51] p < 0.0001

Values are given as Spearman correlation (r) with respective 95% confidence interval and p-value.