Table 4.

Evaluation of biomarkers as prognostic for ALSFRS-R variation over 6, 9, and 12 months in relation to the baseline value of ALSFRS-R.

Parameter	Month 6 (n = 18)	Month 9 (n = 17)	Month 12 (n = 17)
Aβ1-42	−0.19 [−0.61; 0.32] p = 0.44	0.30 [−0.22; 0.69] p = 0.23	−0.36 [−0.72; 0.16] p = 0.16
Phospho-Tau	−0.46 [−0.77; 0.03] p = 0.06	−0.50 [−0.80; 0.01] p = 0.04	−0.17 [−0.61; 0.35] p = 0.50
Total Tau	−0.54 [−0.82; −0.07] p = 0.02	−0.24 [−0.65; 0.29] p = 0.36	−0.23 [−0.61; 0.23] p = 0.31
IATI	0.20 [−0.31; 0.62] p = 0.43	0.37 [−0.15; 0.73] p = 0.14	0.01 [−0.48; 0.50] p = 0.96
Ratio Aβ1-42/p-Tau	0.28 [−0.23; 0.67] p = 0.27	0.43 [−0.07; 0.76] p = 0.08	−0.05 [−0.45; 0.53] p = 0.85
p-Tau/total Tau	0.44 [−0.05; 0.76] p = 0.07	0.50 [0.01; 0.80] p = 0.04	0.22 [−0.31; 0.64] p = 0.40