A map of how disease-related FLNC mutations are distributed on FLNC domains. Calponin homology (CH) domains are marked with red; Ig-like domains are numbered from 1 to 24 and marked with light blue. Mutations reported in the literatures are mapped to the protein structure. Mutated positions are labeled in color in accordance with the type of mutations: black, missense/nonsense; blue, small insertions; red, deletion; purple, frame shift. Mutation resulted in protein aggregate is underlined. Assignment of FLNC mutations to the corresponding domain structure was based on the UniProt database. Distal myopathy (DM), Myofibrillar myopathy (MFM), Hypertrophic cardiomyopathy (HCM), Restrictive cardiomyopathy (RCM), Dilated cardiomyopathy (DCM), Arrhythmic cardiomyopathy (ACM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Cardiac arrhythmias (CA), Arrhythmogenic bileaflet mitral valve prolapse syndrome (ABiMVPS), Left ventricular non compaction (LVNC), Limb-girdle muscular dystrophy (LGMD).