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Characteristics of aflibercept release.
| DDS formulation | Drug total load amount (μg) | Initial burst release (μg) | Release rate after 7 days (μg/day) | Release time (days) | Final percent release (%) |
|---|---|---|---|---|---|
| 2 mM DDS-10 | 99.45 ± 10.06 | 37.35 ± 4.92 | 0.11(r2 = 0.92) | 204 | 66.56 ± 1.35 |
| 2 mM DDS-20 | 193.93 ± 5.56 | 74.03 ± 8.23 | 0.15(r2 = 0.95) | 204 | 61.84 ± 2.31 |
| 3 mM DDS-10 | 98.70 ± 4.81 | 38.62 ± 2.78 | 0.07(r2 = 0.94) | 204 | 70.02 ± 1.91 |
| 3 mM DDS-20 | 190.72 ± 7.77 | 74.56 ± 6.16 | 0.14(r2 = 0.97) | 204 | 66.78 ± 1.56 |
