. Author manuscript; available in PMC: 2021 Jan 1.

Published in final edited form as: J Physiol. 2019 Dec 31;598(2):381–401. doi: 10.1113/JP278952

Table 1.

Biophysical properties of WT and mutant SCN8A channel

		WT	n	R850Q	n	T767I	n	R1617Q	n	R1872Q	n
Maximal transient I	(pA/pF)	−258.0 ± 38.81	25	−302.1 ± 27.95	37
		−756.8 ± 147.2	10			−552.7 ± 68.49	20
		−351.0 ± 78.56	12					−333.2 ± 58.85	15
		−498.1 ± 95.49	21							−861.00 ± 97.40^*	25
Transient I decay (−10mV)	(ms)	0.89 ± 0.03	18	0.97 ± 0.04	28	0.80 ± 0.02^*	19	3.49 ± 0.15^****	14	1.52 ± 0.06^****	24
Activation	V_1/2 (mV)	−21.07 ± 0.79	21	−25.61 ± 0.67^****	31	−31.68 ± 0.81^****	21	−21.25 ± 0.73	14	−25.5 ± 0.83^***	27
Activation	K	6.89 ± 0.20	21	9.26 ± 0.13^****	31	6.29 ± 0.15^*	21	6.76 ± 0.16	14	5.69 ± 0.20^***	27
Inactivation	V_1/2 (mV)	−67 ± 0.66	19	−66.95 ± 0.64	36	−68.20 ± 0.60	20	−67.64 ± 0.65	12	−61.69 ± 0.61^****	24
Inactivation	K	5.30 ± 0.38	19	5.66 ± 0.37^**	36	5.41 ± 0.49	20	10.07 ± 0.67^****	12	5.39 ± 0.36	24
Recovery (τ)	(ms)	13.2 ± 0.72	19	12.48 ± 0.53	29	12.39 ± 0.42	18	5.33 ± 0.20^****	15	12.57 ± 0.71	21
Persistent I (−10mV)	(%)	0.52 ± 0.03	23	1.33 ± 0.06^****	22	1.21 ± 0.06^**	17	2.68 ± 0.20^****	14	0.79 ± 0.05	19
Resurgent I (−35mV)	(%)	5.50 ± 0.23	15	7.40 ± 0.53^**	17	7.91 ± 0.42^****	13	14.13 ± 0.72^****	18	6.07 ± 0.45	16
Resurgent I decay (−35mV)	(ms)	7.25 ± 0.09	12	11.35 ± 0.44^****	13	11.24 ± 0.29^****	12	8.33 ± 0.37^*	15	17.52 ± 1.29^****	15
Resurgent I decay (−10mV)	(ms)	10.46 ± 0.43	12	11.18 ± 0.44	13	11.98 ± 0.62	10	25.87 ± 1.26^****	16	15.51 ± 0.89^**	14

^****

P < 0.0001,

^***

P < 0.001,

^**

P < 0.01,

P < 0.05 in unpaired t test