Table 3.

Biophysical properties of modeled WT and mutant SCN8A channel

		WT	R850Q	T767I	R1617Q	R1872Q
Transient I	(pA/pF)	−714.6	−713.2	−735.3	−724.5	−716.7
Transient I decay		0.92	1.06	0.85	2.01	1.30
Activation	V1/2(mV)	−31.23	−35.78	−40.59	−30.92	−35.59
	K	6.90	8.08	6.73	6.45	6.60
Inactivation	V1/2(mV)	−55.85	−56.16	−56.41	−53.86	−51.57
	K	3.84	3.74	4.00	6.15	3.96
Recovery	(ms)	3.30	3.35	3.36	1.68	3.26
Resurgent I	(%)	3.50	5.93	5.40	7.43	5.85