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. 2020 May 12;20:160. doi: 10.1186/s12935-020-01241-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — The expression of circ_100565 in NSCLC tissues and cells. a Heat map: differential expression of circRNAs in NSCLC tissues (NSCLC) and adjacent normal tissues (Normal). b Circ_100565 was markedly upregulated by more than 2.99-fold in NSCLC compared with that in Normal. c–h QRT-PCR was used to measure the first 3 up-regulated circRNAs and first 3 down-regulated circRNAs in 10 pairs of NSCLC tissues and normal tissues (NC). i The expression of circ_100565 in NSCLC and Normal was detected by qRT-PCR. j Kaplan–Meier analysis examined the correlation between circ_100565 expression and overall survival of NSCLC patients. k Circ_100565 expression in NSCLC cell lines (Calu-3, Calu-6, A549 and H1299) and HBE1 cells was determined by qRT-PCR. l The expression levels of circ_100565 and GAPD in A549 and H1299 cells were assessed by qRT-PCR to evaluate the authenticity of circ_100565. m Subcellular fractionation assay was used to measure the expression levels of circ_100565, U6 and GAPDH in the nuclear and cytoplasm of A549 and H1299 cells. *P < 0.05, **P < 0.01, ***P < 0.001