Table 2.
Bivariate association between Trypanosoma cruzi infection and serum chemokines/cytokines levels above the median or detectable values
| Biomarkers* | Percentage above the global median | P value | ||
|---|---|---|---|---|
| NI | CH (N) ECG | CH (Ab) ECG | ||
| Chemokines (cut-offs) | ||||
| CCL2 (≥ 50.24 pg/ml) | 33.3 | 31.4 | 33.8 | 0.843 |
| CXCL9 (≥ 3485.80 pg/ml) | 21.9 | 47.6 | 54.4 | < 0.001 |
| CXCL10 (≥ 4014.77 pg/ml) | 23.8 | 46.2 | 50.0 | < 0.001 |
| CCL5 (< 630.37 pg/ml) | 36.4 | 22.9 | 31.3 | < 0.001 |
| CXCL8 (≥ 4.41 pg/ml) | 33.8 | 30.0 | 32.0 | 0.553 |
| Cytokines (cut-offs) | ||||
| IL-1β (≥ 0.01 pg/ml) | 12.2 | 41.9 | 37.1 | < 0.001 |
| IL-6 (≥ 1.65 pg/ml) | 32.4 | 29.5 | 37.5 | 0.153 |
| TNF (≥ 0.01 pg/ml) | 16.8 | 17.6 | 18.0 | 0.892 |
| IL-12 (≥ 0.01 pg/ml) | 7.6 | 6.7 | 8.8 | 0.668 |
| IL-10 (≥ 0.07 pg/ml) | 32.8 | 33.3 | 39.3 | 0.138 |
CH Chagas disease patients, NI Non-infected subjects, N Normal, Ab Abnormal, ECG Electrocardiogram, TNF Tumor necrosis factor, IL-6 Interleukin 6, IL-1β Interleukin 1 beta, IL-10 Interleukin 10, IL-12 Interleukin 12, CXCL9 C-X-C motif chemokine ligand-9, CCL5 C-C motif chemokine ligand 5, CXCL10 C-X-C motif chemokine ligand-10, CXCL8 C-X-C motif ligand 8, CCL2 C-C motif chemokine ligand 2
*Cut-offs points above the median except for IL-1β, TNF, IL-12 and IL-10 (detectable values). P value: from chi-square test. Altered levels according to cut-offs. P value of chi-square test