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. 2020 May 12;15:170. doi: 10.1186/s13018-020-01692-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Tenascin-C and Scleraxis are expressed specifically in tenocytes. a Intact digital tendons were removed from the right and left hind paws of mice for tenocyte isolation. The tendon sheath is indicated by arrows and was removed before digestion to ensure a pure population of intrinsic tenocytes. Scale bar = 1 cm. Representative images of Tenascin C (b–g) and Scleraxis (h–m) staining in tenocyte and fibroblast cells isolated from Flii^+/−, WT and Flii^Tg/Tg mice. Positive staining was detected in tenocyte cells for both Tenascin-C and Scleraxis, and no expression was noted in fibroblasts. Magnification × 20, scale bar = 100 μM. Graphical representation of mean fluorescence intensity of Tenascin C (n) and Scleraxis (o) staining. Tenascin-C staining was significantly higher in Flii^+/− cells compared to WT and Flii^Tg/Tg cells. Data is represented as mean ± SEM. *p ≤ 0.05, **p ≤ 0.01, n = 6