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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Bioorg Med Chem Lett. 2020 Mar 28;30(11):127144. doi: 10.1016/j.bmcl.2020.127144

Table 1.

The IC50 and Emax values of chalcones synthesized from Scheme 1 for K-Ras dissociation from the PM

graphic file with name nihms-1585627-t0006.jpg
Compound X R1 R2 IC50 (μM) S.E.M. Emax S.E.M.
1 C-H 4’-NO2 3,4,5-OCH3 7.01 0.92 0.57 0.04
2 C-H 4’-NH2 3,4,5-OCH3 9.17 3.12 0.54 0.03
3 N H 3,4,5-OCH3 52.97 2.96 0.45 0.02
4 C-H 2’,6’-F2 3,4,5-OCH3 8.20 1.80 0.45 0.03
5 C-H 4’-F 3,4,5-OCH3 15.90 8.23 0.39 0.02
6 C-H 4’-Br 3,4,5-OCH3 24.64 2.39 0.47 0.02
7 C-H 4’-OCH3 3,4,5-OCH3 8.29 2.19 0.45 0.05
8 C-H 4’-N(CH3)2 3,4,5-OCH3 7.42 0.53 0.58 0.03
9 C-H 3’,4’,5’-OCH3 4-NO2 8.20 2.87 0.46 0.02
10 C-H 3’,4’,5’-OCH3 2,6-F2 7.49 2.69 0.45 0.01

IC50: 50% inhibitory concentration for K-RasG12V PM dissociation

Emax: Maximal effects elicited by the compounds

S.E.M.: Standard error of mean