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. 2020 May 11;17:154. doi: 10.1186/s12974-020-1731-x

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Inhibition of CCI-induced neuropathic pain in rats by a single intrathecal injection of BMSCs. Paw withdrawal mechanical threshold (a) and paw withdrawal thermal latency (b) were reduced after CCI in rats. In contrast, early intrathecal treatment (1 day after sham or CCI surgery) with BMSCs recovered mechanical allodynia and thermal hyperalgesia in a dose-dependent manner in CCI rats. c Rotarod test for the evaluation of motor function. Arrows in (a, b) indicated the time of BMSCs injection. The data are expressed as the means ± SD (n = 8 in each group). **P < 0.01 versus the CCI group; ^##P < 0.01 versus the Sham group. Statistical significance was determined by two-way analysis of variance (ANOVA) with post hoc Tukey test