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. 2020 May 11;13:73. doi: 10.1186/s13041-020-00616-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — 1-O-acetylgeopyxin A inhibits total Ca²⁺ currents in dorsal root ganglion (DRG) sensory neurons. a Representative traces of total Ca²⁺ currents from DRG sensory neurons treated with 0.1% DMSO (control) or 20 μM 1-O-acetylgeopyxin A. Currents were evoked by 200 ms pulse between − 70 and + 60 mV. b, c Summary of the normalized (pA/pF) total Ca²⁺ current density versus voltage relationship (b) and peak total Ca²⁺ current density at + 10 mV (mean ± SEM) (c) from DRG sensory neurons treated as indicated. (d, e) Boltzmann fits for normalized conductance, G/Gmax, voltage relations for voltage dependent activation (d) and inactivation (e) of sensory neurons treated as indicated. V_1/2 values for activation and inactivation are presented in Table 1. Asterisks indicate statistical significance compared with cells treated with 0.1% DMSO (*P < 0.05, unpaired two-tailed Student’s t test, n = 21 per condition)