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. 2020 May 11;13:73. doi: 10.1186/s13041-020-00616-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — 1-O-acetylgeopyxin A inhibits TTX-sensitive Na + currents in dorsal root ganglion (DRG) neurons. a,c Representative traces of TTX-sensitive (a) and TTX-resistant (b) Na⁺ currents from DRG sensory neurons treated with 0.1% DMSO (control) or 20 μM 1-O-acetylgeopyxin A. b, d Summary (± SEM) of the peak TTX-sensitive (b) or TTX-resistant (d) Na⁺ current density (mean ± SEM) from DRG neurons treated as indicated. TTX-sensitive and TTX-resistant fractions were calculated as described in the Methods section. Asterisk indicate statistical significance compared with cells treated with 0.1% DMSO (*P < 0.05, unpaired two-tailed Student’s t test, n = 15–18 per condition, Mann−Whitney test)