Table 1.
Effects of 1-O-acetylgeopyxin A on gating properties of Voltage-Gated Channels in DRG Neuronsa
| Calcium Total | ||
| DMSO | 1-O-acetylgeopyxin A (20 μM) | |
| Activation | ||
| V1/2 (P = 0.0188) | −3.9 ± 0.8 (21) | −6. 7± 0.8 (21)*b |
| k (P = 0.1966) | 7.1 ± 0.7 (21) | 8.4 ± 0.7 (21) |
| Inactivation | ||
| V1/2 (P = 0.0363) | −26.8 ± 0.8 (19) | −24.0 ± 1.0 (20)*b |
| k (P = 0.8775) | −12.8 ± 0.8 (19) | −12.6 ± 1.0 (20) |
| Sodium | ||
| DMSO | 1-O-Acetylgeopyxin A (20 μM) | |
| Activation | ||
| V1/2 (P = 0.0001) | −20.1 ± 0.7 (16) | −14.9 ± 0.8 (19)*b |
| k (P = 0.0013) | 4.4 ± 0.6 (16) | 7.7 ± 0.7 (19)*b |
| Inactivation | ||
| V1/2 (P = 0.0006) | −47.4 ± 1.0 (15) | −40.6 ± 1.4 (18)*b |
| k (P = 0.1244) | −10.9 ± 0.9 (15) | −13.5 ± 1.3 (18) |
aValues are means±SEM calculated from fits of the data from the indicated number of individual cells to the Boltzmann equation; V1/2 midpoint potential (mV) for voltage-dependent activation or inactivation; k, slope factor. bSignificantly different from the value for DMSO (*P < 0.05; Student’s t test)