FIGURE 5.

Systemic inflammatory protein profiles in healthy subjects, patients with IBS, and patients with UC in remission with IBS-like symptoms. Protein expression in serum was analyzed by proximity extension assay and is presented in arbitrary unit NPX. A, Score scatter plot and (B) loading column plot from an OPLS-DA based on 21 serum proteins (VIP > 0.9) analyzed in relation to patients with IBS (n = 37, gray) and UCR + IBS (n = 19, white) as y-variables. C, Score scatter plot from an OPLS-DA based on all 77 serum proteins analyzed in relation to patients with IBS (n = 37, gray) and HS (n = 19, white) as y-variables. R2Y defines the goodness of fit, and Q2 the goodness of prediction. Serum protein levels of IL6 (D) and FGF21 (E) in IBS (n = 37) and HS (n = 19). Statistical difference between groups was assessed by the Mann-Whitney U test, followed by false discovery rate analysis including all the 77 proteins, and is shown as q values. Each symbol represents 1 individual, and horizontal lines indicate the median of the group.