Table 1.
Cohort Demographics
| VEO | Intermediate | Older Onset | |||
|---|---|---|---|---|---|
| (n = 229) | (n = 221) | (n = 521) | P VEO vs Intermediate | P VEO vs Older Onset | |
| Female | 95 (41.5) | 103 (46.6) | 227 (43.6) | ns | ns |
| Age at Diagnosis (Years) a | 3.9 (2.5–4.8) | 8.0 (6.9–9.2) | 13.3 (11.7–15.3) | n/a | n/a |
| Ethnicity | P < 0.001 | P < 0.0001 | |||
| Not Hispanic or Latino | 200 (87.3) | 204 (92.3) | 494 94.8) | ||
| Hispanic or Latino | 28 (12.2) | 7 (3.2) | 24 (4.6) | ||
| Unknown | 1 (0.4) | 10 (4.5) | 3 (0.6) | ||
| Race | ns | P < 0.01 | |||
| White | 188 (82.1) | 177 (80.1) | 413 (79.3) | ||
| Black | 16 (7.0) | 27 (12.2) | 60 (11.5) | ||
| Asian | 15 (6.6) | 8 (3.6) | 8 (1.5) | ||
| American Indian or Alaska Native | 0 (0) | 1 (0.5) | 2 (0.4) | ||
| Multiple Races | 4 (1.7) | 1 (0.5) | 7 (1.3) | ||
| Unknown | 6 (2.6) | 7 (3.2) | 31 (6.0) | ||
| Continent of Origin | ns | ns | |||
| Europe | 73 (31.9) | 14 (6.3) | 11 (2.1) | ||
| North America | 14 (6.1) | 9 (4.1) | 5 (1.7) | ||
| Asia | 14 (6.1) | 4 (1.8) | 0 (0) | ||
| Middle East Region | 4 (1.7) | 0 (0) | 0 (0) | ||
| South America | 3 (1.3) | 0 (0) | 0 (0) | ||
| Africa | 2 (0.9) | 0 (0) | 0 (0) | ||
| Multiple | 48 (21.0) | 8 (3.6) | 1 (0.2) | ||
| Unknown | 71 (31.0) | 186 (84.2) | 504 (96.7) | ||
| Disease Type | ns | ns | |||
| Crohn’s Disease | 129 (56.3) | 130 (58.8) | 328 (63.0) | ||
| Ulcerative Colitis | 30 (13.1) | 26 (11.8) | 64 (12.3) | ||
| IBD-U | 70 (30.6) | 65 (29.4) | 129 (24.8) | ||
| Crohn’s Disease Phenotype | P < 0.05 | P < 0.0001 | |||
| B1 Inflammatory, Nonpenetrating and Nonstricturing | 112 (86.8) | 98 (75.4) | 217 (66.2) | ||
| B2 Stricturing | 12 (9.3) | 22 (16.9) | 62 (18.9) | ||
| B3 Penetrating | 5 (3.9) | 4 (3.1) | 20 (6.1) | ||
| B2B3 Stricturing and Penetrating | 0 (0) | 6 (4.6) | 29 (8.8) | ||
| Crohn’s Disease Location | P < 0.0001 | P < 0.0001 | |||
| L2 Colonic Only | 59 (45.7) | 29 (22.3) | 50 (15.2) | ||
| L3 Ileocolonic | 54 (41.9) | 89 (68.5) | 233 (71.0) | ||
| L4a/L4b Small Bowel | 3 (2.3) | 12 (9.2) | 45 (13.7) | ||
| Panenteric | 13 (10.1) | 0 (0) | 0 (0) | ||
| Perianal | 29 (24) | 22 (17) | 59 (18) | ns | ns |
| Extent of Ulcerative Colitis | ns | ns | |||
| E1 Ulcerative Proctitis (rectum only) | 1 (3) | 1 (4) | 5 (8) | ||
| E2 Left sided UC (distal to the splenic flexure only) | 7 (23.3) | 5 (19.2) | 11 (17.2) | ||
| E3 Extensive UC (extends proximal to the splenic flexure) | 2 (6.7) | 2 (7.7) | 10 (15.6) | ||
| E4 Pancolitis | 20 (66.7) | 18 (69.2) | 38 (59.4) |
Total counts (percentages) are shown unless otherwise noted.
aReported as median (IQR).