TABLE 2.

Result of Univariable MR analysis.

Gene	Tissue	N. of IVs	IVW- β	IVW- se	IVW- p-value	WME- β	WME- se	WME- p-value	MR-ER - β	MR-ER- se	MR-ER- p-value	IVW Bootstrap - β [CI]
CCL2	FCTX	13	0.064	00.084	0.444	–0.013	0.120	0.914	0.407	0.297	0.198	0.058[−0.102;0.234]
	CRBL	9	–0.034	0.106	0.747	–0.049	0.140	0.727	0.243	0.440	0.599	−0.037[−0.246;0.161]
	OCTX	10	0.257	0.096	0.007	0.224	0.131	0.087	0.552	0.496	0.297	0.246[0.058;0.443]
	PUTM	10	0.111	0.098	0.255	0.210	0.130	0.107	0.245	0.384	0.542	0.107[−0.076;0.291]
	WHMT	6	–0.044	0.146	0.761	–0.141	0.188	0.453	–0.122	0.708	0.871	−0.041[−0.326;0.255]
	SNIG	13	0.076	0.079	0.336	0.137	0.107	0.201	0.435	0.321	0.203	0.072[−0.074;0.226]
	THAL	10	0.197	0.112	0.079	0.377	0.146	0.010	0.143	0.641	0.829	0.191[−0.011;0.397]
	HIPP	4	–0.028	0.196	0.887	–0.006	0.240	0.981	0.704	0.796	0.470	−0.181[−0.542;0.151]
	MEDU	11	0.272	0.083	0.001	0.276	0.133	0.039	0.217	0.267	0.436	0.260[0.092;0.437]
	TCTX	11	–0.008	0.091	0.932	0.127	0.127	0.318	–0.097	0.443	0.832	−0.007[−0.191;0.184]
CXCL10	FCTX	7	0.079	0.141	0.574	0.194	0.185	0.294	0.835	0.565	0.200	0.077[−0.214;0.365]
	CRBL	10	0.173	0.100	0.084	0.261	0.136	0.056	0.291	0.317	0.386	0.166[−0.019;0.369]
	OCTX	13	–0.062	0.095	0.514	–0.179	0.136	0.189	–0.745	0.350	0.057	−0.063[−0.249;0.127]
	PUTM	13	–0.161	0.089	0.070	–0.134	0.126	0.287	0.111	0.440	0.806	−0.150[−0.324;0.031]
	WHMT	12	0.066	0.086	0.445	0.073	0.109	0.504	0.135	0.373	0.725	0.060[−0.109;0.233]
	SNIG	7	–0.060	0.083	0.468	–0.051	0.109	0.636	–0.301	0.265	0.307	−0.064[−0.227;0.096]
	THAL	19	0.128	0.066	0.054	0.016	0.102	0.875	0.111	0.237	0.646	0.122[−0.006;0.255]
	HIPP	14	0.037	0.101	0.713	0.202	0.129	0.117	–0.175	0.395	0.665	0.032[−0.147;0.212]
	MEDU	7	0.080	0.095	0.400	–0.036	0.132	0.784	–0.318	0.462	0.522	0.075[−0.103;0.273]
	TCTX	17	0.001	0.073	0.991	–0.041	0.099	0.677	–0.232	0.240	0.348	−0.002[−0.136;0.131]
MAPK14	FCTX	12	–0.135	0.085	0.111	–0.249	0.120	0.038	–0.350	0.294	0.262	−0.127[−0.286;0.041]
	CRBL	7	0.010	0.126	0.938	–0.019	0.167	0.909	–0.354	0.550	0.548	0.007[−0.235;0.258]
	OCTX	16	–0.165	0.096	0.085	–0.243	0.136	0.073	–0.261	0.354	0.473	−0.154[−0.336;0.031]
	PUTM	12	–0.159	0.085	0.060	–0.179	0.116	0.124	–1.641	0.837	0.078	−0.49[−0.315;0.016]
	WHMT	6	–0.400	0.187	0.033	–0.182	0.225	0.419	0.528	0.490	0.341	−0.379[−0.731;−0.067]
	SNIG	18	–0.023	0.067	0.725	–0.050	0.097	0.608	0.407	0.289	0.179	−0.023[−0.160;0.116]
	THAL	9	–0.083	0.139	0.551	–0.113	0.180	0.529	–0.212	0.461	0.659	−0.079[−0.346;0.170]
	HIPP	14	–0.098	0.076	0.198	–0.024	0.101	0.809	–0.191	0.454	0.682	−0.097[−0.258;0.059]
	MEDU	8	–0.083	0.098	0.397	–0.114	0.136	0.402	0.194	0.329	0.577	−0.083[−0.286;0.114]
	TCTX	13	–0.113	0.090	0.208	–0.111	0.122	0.364	0.071	0.342	0.838	−0.108[−0.276;0.057]
NFKB1	FCTX	9	0.306	0.127	0.016	0.253	0.177	0.152	0.706	0.563	0.250	0.290[0.042;0.545]
	CRBL	9	0.332	0.103	0.001	0.421	0.144	0.003	0.452	0.360	0.250	0.312[0.103;0.543]
	OCTX	15	–0.025	0.072	0.724	0.009	0.100	0.926	–0.193	0.265	0.479	−0.025[−0.156;0.102]
	PUTM	16	–0.069	0.082	0.405	–0.115	0.115	0.317	0.716	0.529	0.198	−0.065[−0.219;0.107]
	WHMT	13	–0.037	0.091	0.684	–0.029	0.128	0.821	–0.676	0.548	0.243	−0.037[−0.222;0.142]
	SNIG	14	–0.090	0.080	0.259	–0.048	0.111	0.667	0.469	0.420	0.286	−0.081[−0.238;0.063]
	THAL	11	0.134	0.101	0.186	0.127	0.129	0.325	0.321	0.458	0.501	0.126[−0.077;0.347]
	HIPP	11	–0.121	0.096	0.207	–0.092	0.136	0.500	0.262	0.465	0.587	−0.118[−0.317;0.061]
	MEDU	12	0.023	0.099	0.815	–0.045	0.137	0.744	0.127	0.485	0.799	0.021[−0.172;0.221]
	TCTX	16	–0.112	0.083	0.178	–0.104	0.116	0.373	0.158	0.375	0.681	−0.105[−0.262;0.062]
TNFRS1A	FCTX	17	–0.038	0.075	0.611	0.030	0.108	0.781	–0.342	0.310	0.287	−0.037[−0.187;0.101]
	CRBL	14	0.037	0.090	0.683	0.038	0.125	0.761	–0.158	0.298	0.604	0.037[−0.137;0.213]
	OCTX	11	0.097	0.095	0.312	0.101	0.129	0.434	0.205	0.275	0.474	0.093[−0.094;0.277]
	PUTM	11	0.096	0.082	0.237	0.085	0.111	0.443	–0.231	0.379	0.557	0.092[−0.065;0.248]
	WHMT	12	0.202	0.101	0.046	0.212	0.135	0.116	0.062	0.401	0.880	0.191[−0.0001;0.340]
	SNIG	8	–0.173	0.109	0.111	–0.177	0.147	0.231	0.376	1.190	0.763	−0.165[−0.388;0.051]
	THAL	16	0.153	0.085	0.072	0.030	0.121	0.803	–0.113	0.341	0.744	0.147[−0.028;0.324]
	HIPP	11	0.051	0.101	0.614	0.112	0.131	0.392	–0.601	0.456	0.221	0.043[−0.159;0.246]
	MEDU	11	0.150	0.097	0.121	0.259	0.123	0.035	0.259	0.295	0.402	0.142[−0.028;0.319]
	TCTX	10	–0.321	0.113	0.005	–0.359	0.157	0.022	–0.085	0.574	0.886	−0.312[−0.550;−0.102]

The table reports for each gene and for each tissue, the number of IVs, the causal effect β, its standard error and p-value for IVW, WME and MR-ER methods. In the last column the IVW estimate and its 95% confidence intervals obtained via bootstrap are also reported. CRBL, cerebellum; FCTX, frontal cortex; HIPP, hippocampus; MEDU, medulla; OCTX, occipital cortex; PUTM, putamen; SNIG, substantia nigra; THAL, thalamus; TCTX, temporal cortex; WHMT, intralobular white matter. IVW, Inverse Variance Weighted; WME, Weighted Median Estimator; MR-ER, Egger estimator.