Table 4.
Transcripts altered in the striatum of MSA patients overlapping networks affected in Alzheimer’s disease pathology. Genes were identified by disease enrichment analysis in IPA with a P value for the group interaction = 5.52E-22. Fold change expression levels were calculated for MSA cases in comparison to controls, P value as per t test
| Gene ID | Accession # | Log2 fold change | P value |
|---|---|---|---|
| NGFR | NM_002507.3 | 2.99 | 0.00341 |
| MOG | NM_001008228.2 | 2.26 | 0.00041 |
| CD14 | NM_000591.2 | 2.12 | 0.00112 |
| TF | NM_001063.2 | 1.9 | 0.00240 |
| MAG | NM_001199216.1 | 1.56 | 0.00310 |
| GFAP | NM_002055.4 | 1.39 | 0.01190 |
| SOD2 | NM_000636.2 | 1.36 | 0.00414 |
| TGFB1 | NM_000660.4 | 1.27 | 0.00014 |
| STAT3 | NM_003150.3 | 1.13 | 0.00022 |
| ATF4 | NM_001675.2 | 1.05 | 0.00105 |
| BACE1 | NM_012104.3 | 0.823 | 0.00473 |
| BCL2L1 | NM_138578.1 | 0.695 | 0.01150 |
| SORL1 | NM_003105.5 | 0.676 | 0.03580 |
| JUN | NM_002228.3 | 0.657 | 0.00922 |
| TGFBR2 | NM_001024847.1 | 0.646 | 0.00901 |
| BAX | NM_138761.3 | 0.517 | 0.00884 |
| NFE2L2 | NM_006164.3 | 0.498 | 0.01130 |
| PRKCA | NM_002737.2 | 0.262 | 0.00766 |
| BECN1 | NM_003766.2 | 0.196 | 0.04030 |
| ABAT | NM_020686.5 | −0.434 | 0.02630 |
| GRIA2 | NM_001083620.1 | −0.594 | 0.04140 |
| THY1 | NM_006288.2 | −0.754 | 0.02930 |
| CAMK2B | NM_001220.3 | −0.778 | 0.04300 |
| CACNB2 | NM_000724.3 | −0.889 | 0.04170 |
| PRKCB | NM_212535.1 | −0.963 | 0.04430 |
| PPP3CA | NM_000944.4 | −1.17 | 0.04700 |
| SLC1A2 | NM_004171.3 | −1.39 | 0.00040 |
| CALB1 | NM_004929.2 | −2.04 | 0.00062 |