. Author manuscript; available in PMC: 2020 May 12.

Published in final edited form as: Mol Neurobiol. 2019 Apr 9;56(10):7003–7021. doi: 10.1007/s12035-019-1577-3

Table 5.

Alterations in selected miRNAs in MSA is associated with inverse changes in transcription in target genes. In silico analysis of miRNAs deregulated in MSA brains and their target mRNAs that also showed differential expression in MSA. Coefficients (r) correspond to Pearson’s correlation.

ID	Fold change	P value	Symbol	Log₂ fold	P value	Correlat. r	P value
hsa-let-7b-5p	1.66	0.0006	AP1S1	−0.86	0.0131	−0.223	0.3738
			GNPTAB	−0.54	0.0198	−0.176	0.4831
			RASGRP1	−1.03	0.0271	−0.200	0.4253
hsa-miR-100-5p	1.98	0.0001	PPP3CA	−1.17	0.0470	−0.688^**	0.0016
hsa-miR-10a-5p	1.26	0.0074	CAMK2B	−0.77	0.0430	−0.039	0.8756
hsa-miR-1185-5p	−1.36	0.0092	GNG2	1.51	0.0288	−0.291	0.2411
hsa-miR-124-3p	−1.78	0.0007	CCL2	3.99	7.5E-05	−0.343	0.1625
			STAT3	1.13	0.0002	−0.647^**	0.0037
			SERPINB6	0.87	0.0006	−0.695^**	0.0014
			DNM2	1.68	0.0020	−0.598^**	0.0087
			CERS2	1.22	0.0049	−0.753^***	0.0003
			GSN	1.21	0.0059	−0.632^**	0.0049
			FA2H	1.36	0.0084	−0.710^***	0.0010
			STX2	0.63	0.0184	−0.695^**	0.0014
			GNG2	1.51	0.0288	−0.339	0.1685
hsa-miR-1249-3p	1.48	0.0102	SOX9	−0.47	0.0084	−0.490^*	0.0389
hsa-miR-128-3p	−1.66	0.0120	IL13RA1	0.89	0.0050	−0.711^***	0.0009
			NOVA1	0.27	0.0082	−0.474^*	0.0465
hsa-miR-132-3p	−1.61	0.0331	MECP2	0.24	0.0099	−0.439	0.0679
			NFE2L2	0.49	0.0113	−0.659^**	0.0029
hsa-miR-148a-3p	−2.39	0.0019	UGT8	1.36	0.0093	−0.693^**	0.0014
hsa-miR-149-5p	−1.30	0.0420	CSF1	1.37	0.0009	−0.562^*	0.0151
hsa-miR-154-5p	−1.47	0.0024	JAM3	1.19	0.0007	−0.603^**	0.0080
hsa-miR-155-5p	1.48	0.0004	LCLAT1	−0.53	0.0040	−0.430	0.0749
hsa-miR-15a-5p	1.43	0.0058	EGFR	−0.52	0.0027	−0.249	0.3191
			PPP2R5C	−0.56	0.0060	−0.548^*	0.0184
			AKT3	−0.41	0.0271	−0.391	0.1086
hsa-miR-181a-5p	2.15	0.0001	GRIA2	−0.59	0.0414	−0.521^*	0.0266
hsa-miR-19a-3p	1.59	0.0248	SLC1A2	−1.39	0.0004	−0.645^**	0.0038
			CDS1	−0.76	0.0162	−0.681^**	0.0018
			SLC8A1	−0.54	0.0280	−0.592^**	0.0096
hsa-miR-218-5p	−2.20	0.0005	TNC	2.38	0.0039	−0.546^*	0.0190
			GNAI2	0.62	0.0097	−0.601^**	0.0083
hsa-miR-222-3p	−2.01	0.0424	SOD2	1.36	0.0041	−0.484^*	0.0418
hsa-miR-23b-3p	1.56	0.0010	SEC23A	−0.49	0.0251	−0.473^*	0.0471
hsa-miR-25-3p	1.70	0.0001	SLC12A5	−0.66	0.0345	−0.727^***	0.0006
hsa-miR-27b-3p	1.57	0.0098	CDS1	−0.76	0.0162	−0.681^**	0.0018
			PLCL2	−0.68	0.0251	−0.603^**	0.0080
			PDPK1	−0.36	0.0397	−0.570^*	0.0133
hsa-miR-296-5p	1.69	0.0001	GBA	−0.46	0.0023	−0.482^*	0.0425
			PDPK1	−0.36	0.0397	−0.535^*	0.0220
hsa-miR-299-5p	−1.83	0.0103	GNPTG	0.60	0.0122	−0.785^***	0.0001
hsa-miR-29c-3p	−1.52	0.0048	BACE1	0.82	0.0047	−0.737^***	0.0005
			TNFRSF1A	1.15	0.0047	−0.460	0.0548
			PMP22	0.97	0.0077	−0.724^***	0.0007
			GPR37	0.89	0.0439	−0.558^*	0.0160
hsa-miR-301a-3p	1.52	0.0375	CDS1	−0.76	0.0162	−0.669^**	0.0024
			CALM1	−0.76	0.0279	−0.703^**	0.0011
hsa-miR-30b-5p	−1.66	0.0001	JUN	0.65	0.0092	−0.533^*	0.0225
			GNAI2	0.62	0.0097	−0.475^*	0.0463
			C9orf72	0.68	0.0119	−0.388	0.1108
			STX2	0.63	0.0184	−0.503^*	0.0331
			BECN1	0.19	0.0403	−0.148	0.5560
hsa-miR-376c-3p	−1.47	0.0004	HIF1A	0.42	0.0401	−0.160	0.5238
hsa-miR-423-5p	1.51	0.0031	CALM1	−0.76	0.0279	−0.285	0.2515
			THY1	−0.75	0.0293	−0.309	0.2109
hsa-miR-495-3p	−1.59	0.0033	CD9	0.86	0.0231	−0.693^**	0.0014
hsa-miR-505-3p	−1.47	0.0458	HMGB1	0.54	0.0074	−0.599^**	0.0086
			C9orf72	0.68	0.0119	−0.595^**	0.0091
hsa-miR-520f-3p	1.37	0.0197	AKT3	−0.41	0.0271	−0.122	0.6295
hsa-miR-582-5p	−1.38	0.0141	NOVA1	0.27	0.0082	−0.121	0.6321
			NFE2L2	0.49	0.0113	−0.241	0.3340
hsa-miR-625-5p	1.96	0.0001	CHRNB2	−0.86	0.0403	−0.720^***	0.0007
hsa-miR-744-5p	1.31	0.0224	THY1	−0.75	0.0293	−0.095	0.7050
			SLC12A5	−0.66	0.0345	−0.082	0.7450
			CAMK2B	−0.77	0.0430	−0.041	0.8703
			MAP2K2	−0.25	0.0449	−0.018	0.9430
hsa-miR-9-5p	−1.22	0.0173	TNC	2.38	0.0039	−0.068	0.7872
			BACE1	0.82	0.0047	−0.372	0.1274
			PMP22	0.97	0.0077	−0.329	0.1814

*P < 0.05, **P < 0.01, and ***P < 0.001 for the correlation between miRNA and mRNA levels. Gene names in italic indicate experimental verified effect of miRNA on target; gene names on regular font indicate targets predicted with high confidence (according to TargetScan, Tarbase, and/or miRecords)