Table 5.
Results of sensitivity analyses of risk of systemic autoimmune disease among WTC Health Registry enrolleesa
| Cases that met classification criteria, adjusted RR (95% CI) | Cases diagnosed in 2005 or later, adjusted RR (95% CI) | RA only, adjusted RR (95% CI) | With PTSD, adjusted RR (95% CI) | Without PTSD, adjusted RR (95% CI) | |
|---|---|---|---|---|---|
| Responders | |||||
| Dust intensity | |||||
| Intense | 1.57 (0.66–3.69) | 1.85 (0.99–3.45) | 1.84 (0.85–3.99) | 1.28 (0.37–4.42) | 1.88 (0.94–3.75) |
| None/some | Referent | Referent | Referent | Referent | Referent |
| Dust composite score | |||||
| High | 2.03 (0.84‐4.93) | 1.82 (0.94‐3.53) | 1.81 (0.79‐4.11) | 0.60 (0.12‐3.07) | 2.28 (1.13‐4.61)b |
| Low | Referent | Referent | Referent | Referent | Referent |
| Months worked at WTC site (continuous) | 1.03 (0.86–1.23) | 1.10 (0.98–1.25) | 0.99 (0.83–1.18) | 0.95 (0.73–1.26) | 1.13 (0.99–1.29) |
| PTSD | |||||
| Yes | 1.84 (0.77–4.38) | 1.39 (0.68–2.82) | 1.71 (0.76–3.85) | – | – |
| No | Referent | Referent | Referent | – | – |
| Community members | |||||
| Dust intensity | |||||
| Intense | 2.12 (1.03–4.35)b | 1.45 (0.81–2.61) | 1.33 (0.66–2.69) | 0.46 (0.18–1.21) | 2.40 (1.21–4.75)b |
| None/some | Referent | Referent | Referent | Referent | Referent |
| Dust composite score | |||||
| High | 0.96 (0.29–3.17) | 1.00 (0.39–2.53) | 0.55 (0.13–2.31) | 0.46 (0.06–3.43) | 1.51 (0.58–3.93) |
| Low | Referent | Referent | Referent | Referent | Referent |
| PTSD | |||||
| Yes | 2.63 (1.24–5.56)b | 3.40 (1.90–6.10)b | 3.94 (1.92–8.07)b | – | – |
| No | Referent | Referent | Referent | – | – |
a
All models adjusted for age, sex, race/ethnicity, and smoking history. Models with posttraumatic stress disorder (PTSD) were also adjusted for educational attainment. Every 9/11 exposure or characteristic received its own model. WTC = World Trade Center; RR = risk ratio; 95% CI = 95% confidence interval; RA = rheumatoid arthritis.
b
P = < 0.05.