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Synthesis of phosphoric acid 4 from boronic acid 8 and aryl bromide 7. Conditions and yields for the individual steps a–c: (a) 2.5 equiv 7, 10 mol % Pd(PPh3)4, 10 equiv 2 m Na2CO3 (aq), 85 °C, 16 h (DME), 96 %; (b) 6.0 equiv BBr3, 0 °C→rt, 2 h (CH2Cl2), 83 %; (c) 2.0 equiv POCl3, 95 °C, 12 h (py), then H2O, 95 °C, 54 %.
