Table 3.

Enantioselective silicon‐free SuFEx reactions.^[a]

Enantiomer[b]	Phenol	ee [c]
enantiomer‐1	2 b‐p	73 % (95[d])
	2 ac	<2 %
	6	>99 %
	7	>99 %
enantiomer‐2	2 b‐p	71 % (95[d])
	2 ac	<2 %
	6	>99 %
	7	>99 %

[a] Reaction conditions: enantiomer‐1/enantiomer‐2 (1 mL, 3.6 mm in CH₃CN), phenolic derivative (1 equiv), DBU (1 equiv), rt. When phenolate 6 or 7 was adopted as the substrate, DBU was not added. [b] enantiomer‐1 and enantiomer‐2 refer to two enantiomers with retention times of 16.8 and 18.8 min with chiral HPLC, respectively. [c] ee determined using chiral HPLC and calculated by ee= $\frac{\mathrm{m}\mathrm{a}\mathrm{j}\mathrm{o}\mathrm{r}\mathrm{i}\mathrm{t}\mathrm{y}-\mathrm{m}\mathrm{i}\mathrm{n}\mathrm{o}\mathrm{r}\mathrm{i}\mathrm{t}\mathrm{y}}{\mathrm{m}\mathrm{a}\mathrm{j}\mathrm{o}\mathrm{r}\mathrm{i}\mathrm{t}\mathrm{y}+\mathrm{m}\mathrm{i}\mathrm{n}\mathrm{o}\mathrm{r}\mathrm{i}\mathrm{t}\mathrm{y}}\times 100\%$ , [d] 10 equiv 2 b‐p used.