Figure 4.

Efficacy of eIL‐31‐CuMV_TT vaccine by reduction of lesion scores. A & B, Case report. A, IBH lesion scores of single horse during untreated previous season (gray) and vaccination season (black). B, Antibody titer against eIL‐31 (left y‐axis, black) and CuMV_TT (right y‐axis, gray) of single horse. Vaccinations are indicated by arrows. C‐E, Double‐blind placebo‐controlled randomized clinical study. C, Monthly lesion score of placebo group during untreated (dotted gray line) and placebo‐treated (continuous gray line) season. Statistics is only indicated when significant. D, Monthly lesion score of vaccinated group during untreated (dotted gray line) and eIL‐31‐CuMV_TT vaccinated (continuous black line) season. Statistics is only indicated when significant. E, Delta of monthly lesion scores after booster vaccination from previous IBH season subtracted by placebo‐ or vaccine‐treated season. Mid‐season booster indicated by arrow