Table 2.
Most regulated genes after 1:8 (estimated total particle mass 7.4 µg/cm2) PM exposure. Up‐ and down‐regulated genes with minimum of fivefold difference in gene expression compared with control were included
| Gene | Expression compared with control (fold regulation) | Cell function category52 |
|---|---|---|
| ITGAX | 59 | Immunotoxicity |
| LYZ | 42 | |
| PTPRC | 29 | |
| CD8A | 11 | |
| CYP1A1 | 6.0 | |
| OGG1 | −8.0 | Oxidative stress and DNA damage and repair |
Abbreviations: CD8A, T‐cell surface glycoprotein CD8 alpha chain; CYP1A1, cytochrome P450 1A1; ITGAX, integrin alpha‐X; LYZ, lysozyme C; OGG1, N‐glycosylase/DNA lyase; PTPRC, receptor‐type tyrosine‐protein phosphatase C.