Table 3.
Mean differences in outcome measures associated (P < .05) with paracetamol exposure at 18‐32 wk gestation
| Measure | Na |
AMD (95% CI) |
P trend |
|---|---|---|---|
| Cognition | |||
| IQ: Freedom from distractibility at 8 y | 5448 |
−0.35 (−0.69, −0.00) |
0.048 |
| Temperament | |||
| M.Adaptability at 6 mo | 8166 |
+0.33 (+0.05, +0.60) |
0.019 |
| M.Persistence at 24 mo | 8074 |
+0.36 (+0.12, +0.60) |
0.003 |
| Behaviour | |||
| M.SDQ Hyperactivity at 42 mo | 7849 |
+0.16 (+0.07, +0.25) |
3.3 × 10−4 |
| M.SDQ Hyperactivity at 47 mo | 7508 |
+0.22 (+0.10, +0.33) |
1.8 × 10−4 |
| T.DAWBA Attention at 7‐8 y | 4378 |
+0.45 (+0.11, +0.79) |
0.009 |
| T.DAWBA Attention/Activity at 7‐8 y | 4376 |
+0.53 (+0.02, +1.04) |
0.042 |
| M.SDQ Conduct problems at 42 mo | 7849 |
+0.22 (+0.10, +0.33) |
1.9 × 10−4 |
| M.SDQ Conduct problems at 47 mo | 7508 |
+0.08 (+0.01, +0.15) |
0.023 |
| M.SDQ Conduct problems at 81 mo | 6742 |
+0.10 (+0.02, +0.18) |
0.010 |
|
M.SDQ Total behavioural difficultiesb at 42 mo |
7849 |
+0.54 (+0.26, +0.82) |
1.3 × 10−4 |
|
M.SDQ Total behavioural difficultiesb at 47 mo |
7508 |
+0.31 (+0.08, +0.53) |
0.007 |
For definitions of DAWBA and SDQ see Supplementary Material; the IQ tests were performed by ALSPAC psychologists; the behaviour measures were reported by mothers (labelled ‘M’) within self‐completion questionnaires, with the exception of those labelled ‘T’ which were completed by teachers. Details of outcome measures are given in the Supplementary Material.
AMD, adjusted mean difference of score.
Adjusting for all factors in Table 2.
Combination of hyperactivity, conduct, emotional and peer problems.