Table 4.
Among daughters, mean differences in outcome measures associated with paracetamol exposure at 18‐32 wk gestation
| Measure | Na |
AMD (95% CI) |
P trend |
|---|---|---|---|
| Cognition | |||
| IQ: Freedom from distractibility at 8 y | 2726 |
−0.41 (−0.88, +0.06) |
0.084 |
| Temperament | |||
| M.Adaptability at 6 mo | 3933 |
+0.215 (−0.19,+0.62) |
0.293 |
| M.Persistence at 24 mo | 3883 |
+0.36 (+0.02, +0.70) |
0.039 |
| Behaviour | |||
| M.SDQ Hyperactivity at 42 mo | 3781 |
+0.17 (+0.05, +0.30) |
0.006 |
| M.SDQ Hyperactivity at 47 mo | 3613 |
+0.25 (+0.09, +0.41) |
0.002 |
| T.SDQ Hyperactivity at 7‐8 y | 2177 |
+0.21 (+0.02, +0.40) |
0.033 |
| T.DAWBA Attention at 7‐8 y | 2181 |
+0.66 (+0.27, +1.04) |
0.001 |
| T.DAWBA Attention/Activity at 7‐8 y | 2484 |
−0.11 (−0.41, +0.19) |
0.478 |
| M.SDQ Conduct problems at 42 mo | 3781 |
+0.16 (−0.00, +0.32) |
0.050 |
| M.SDQ Conduct problems at 47 mo | 3613 |
+0.06 (−0.04, +0.16) |
0.273 |
| M.SDQ Conduct problems at 81 mo | 3266 |
+0.08 (−0.03, +0.19) |
0.169 |
| M.SDQ Total behavioural difficultiesb at 42 mo | 3781 |
+0.49 (+0.11, +0.88) |
0.012 |
| M.SDQ Total behavioural difficultiesb at 47 mo | 3613 |
+0.26 (−0.05, +0.57) |
0.100 |
Outcome measures were either included in Table 3, or have shown effects at P < .05. Details of outcome measures are given in the Supplementary Material.
For definitions of DAWBA and SDQ see Supplementary Material; the IQ tests were performed by ALSPAC psychologists; the behaviour measures were reported by mothers (labelled ‘M’) within self‐completion questionnaires, with the exception of those labelled ‘T’ which were completed by teachers.
Adjusting for all factors in Table 2.
Combination of hyperactivity, conduct, emotional and peer problems.