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[Preprint]. 2020 Mar 7:2020.03.04.977736. [Version 1] doi: 10.1101/2020.03.04.977736

Figure 1. Genome comparison analysis of SARS-related CoVs.

Figure 1.

Similarity plot of SARS-related CoVs against human SARS-CoV-2 Wuhan-Hu-1 genome (NC_045512.2), based on a multiple sequence alignment of the whole genomes. Each point represents the percent identity of a 200 bp window of the alignment with a 50 bp step size between each point. The open reading frames of the SARS-CoV-2 genome (NC_045512.2) are shown above the plot. Each colored line corresponds to the nucleotide similarity between the human SARS-CoV-2 genome (NC_045512.2) and the respective SARS-related CoV genome. The red arrows and dashed line surround a region displaying major divergence due to possible recombination within SARS-related CoV genomes. The regions marked by a solid red line highlight fast-evolving regions among the SARS-related CoV genomes. For detailed information about the genomes that were used in this study, refer to Table S1.