. 2019 Jun 17;46(2):171–185. doi: 10.1111/nan.12559

Table 3.

Expression of senescence and DNA damage markers in neurones and glia in the ALS/MND and control cohort

Descriptives	Group	Senescence markers	FACx	MCx	OCx	DNA damage/oxidative stress markers	FACx	MCx
Mean (SD) Median (IQR)	Control	p16, glial	12.18 (6.10) 12.92 (11.55)	20.43 (21.35) 13.46 (37.58)	12.03 (3.28) 12.88 (5.94)	γH2AX, neuronal	22.74 (14.57) 24.27 (26.65)	36.66 (22.81) 37.58 (44.06)
ALS/MND	27.73 (13.81) 24.05 (14.69)	14.46 (11.08) 10.97 (15.99)	14.01 (4.92) 13.51 (6.63)	25.00 (9.91) 24.00 (13.84)	34.65 (30.49) 17.78 (51.34)
Control	p21, glial	32.63 (4.63) 32.15 (8.68)	25.93 (14.64) 28.80 (27.48)	53.82 (11.37) 49.85 (19.63)	γH2AX, glial	40.28 (28.59) 32.64 (50.38)	56.76 (27.25) 61.39 (50.15)
ALS/MND	50.46 (10.66) 47.70 (16.60)	35.23 (14.96) 34.45 (27.75)	62.35 (17.32) 67.00 (33.98)	38.97 (13.07) 42.87 (20.64)	48.22 (33.93) 34.85 (61.36)
Control	p21, neuronal	8.88 (7.87) 8.25 (14.92)	12.40 (10.78) 12.50 (19.40)	56.18 (33.53) 69.35 (56.08)	8‐OHdG, neuronal	78.91 (5.61) 81.50 (8.91)	56.08 (31.20) 55.85 (57.52)
ALS/MND	32.14 (16.56) 35.20 (21.73)	25.72 (18.88) 27.70 (34.85)	61.20 (35.22) 59.30 (55.75)	85.79 (7.91) 87.93 (13.80)	53.52 (24.61) 54.31 (43.59)

Descriptives

Group

Senescence markers

FACx

MCx

OCx

DNA damage/oxidative stress markers

FACx

MCx

Mean (SD)

Median (IQR)

Control

p16, glial

12.18 (6.10)

12.92 (11.55)

20.43 (21.35)

13.46 (37.58)

12.03 (3.28)

12.88 (5.94)

γH2AX, neuronal

22.74 (14.57)

24.27 (26.65)

36.66 (22.81)

37.58 (44.06)

ALS/MND

27.73 (13.81)

24.05 (14.69)

14.46 (11.08)

10.97 (15.99)

14.01 (4.92)

13.51 (6.63)

25.00 (9.91)

24.00 (13.84)

34.65 (30.49)

17.78 (51.34)

Control

p21, glial

32.63 (4.63)

32.15 (8.68)

25.93 (14.64)

28.80 (27.48)

53.82 (11.37)

49.85 (19.63)

γH2AX, glial

40.28 (28.59)

32.64 (50.38)

56.76 (27.25)

61.39 (50.15)

ALS/MND

50.46 (10.66)

47.70 (16.60)

35.23 (14.96)

34.45 (27.75)

62.35 (17.32)

67.00 (33.98)

38.97 (13.07)

42.87 (20.64)

48.22 (33.93)

34.85 (61.36)

Control

p21, neuronal

8.88 (7.87)

8.25 (14.92)

12.40 (10.78)

12.50 (19.40)

56.18 (33.53)

69.35 (56.08)

8‐OHdG, neuronal

78.91 (5.61)

81.50 (8.91)

56.08 (31.20)

55.85 (57.52)

ALS/MND

32.14 (16.56)

35.20 (21.73)

25.72 (18.88)

27.70 (34.85)

61.20 (35.22)

59.30 (55.75)

85.79 (7.91)

87.93 (13.80)

53.52 (24.61)

54.31 (43.59)

Data are expressed as percentage of positive cells in the brain regions under study.

FACx, frontal association cortex; IQR, interquartile range; MCx, motor cortex; MND, motor neuron disease; SD, standard deviation; 8‐OHdG, 8‐hydroxy‐2′‐deoxyguanosine.