Table 3.

Identification of genes based on additive genetic variance explained by windows of 50 adjacent SNP for 305‐day milk yield and lactation curve parameters^a in primiparous cows

Chromosome	Position (bp)	Genesb	Trait (% variance explained)
BTA14	1480260–1683767	MIR2308, LOC104973955, CYHR1, FOXH1, COMMD5, TONSL, PPP1R16A, MFSD3, LRRC24, C14H8orf33, RECQL4, ARHGAP39, RPL8, GPT, LRRC14, ZNF34, C14H8orf82, ZNF7, KIFC2	305‐day milk (1.21), peak yield (1.04), peak time (0.47), ramp (0.37), scale (0.81), decay (0.57)
BTA14	1855090–2118405	LOC100141215, MIR2309, MIR1839, LOC101907640, LOC101908059, LOC104968841, LOC104973958, LOC104973959, LOC104973960, LOC104973961, OPLAH, HGH1, LOC509114, GRINA, PARP10, MAF1, SHARPIN, CYC1, GPAA1, MROH1, LOC523023, EXOSC4, SPATC1, LOC786966	305‐day milk (1.09), peak yield (0.94), peak time (0.38), ramp (0.28), scale (0.73), decay (0.44)
BTA14	2676321–2940147	PSCA, LY6K, LOC100848939, LOC101904969, LOC101905222, LOC104973965, LOC104973966, THEM6, LYNX1, JRK, ARC, SLURP1, LY6D, GML, LOC787628, LYPD2	305‐day milk (0.94), peak yield (0.82), peak time (0.55), ramp (0.37), scale (0.64), decay (0.50)

^aCalculated using the following model (MilkBot model): $y_t=a\left(1-\frac{\exp \left(\frac{c-t}{b}\right)}{2}\right)\exp \left(-\mathrm{d}t\right)$, in this function, a is the scale parameter, representing the theoretical maximum daily yield; b is the ramp parameter, controlling the rate of rise in milk production in early lactation; c is the offset parameter, describing the offset in time between parturition and the start of lactation; and d is the decay parameter, representing the rate of senescence of production capacity. The time at which peak lactation occurred (t _peak) was defined as: $t_{\text{peak}}=-b\ln \left(\frac{2\text{db}}{\text{db}+1}\right)+c$, and peak milk production was calculated by substitution t _peak in the MilkBot equation.

^bOfficial gene symbol (assembly UMD_3.1, annotation release 103).