Table 3. Distribution of the functional responses elicited in the white matter according to the matching analysis with the ROIs of JHU Atlas (cortical and cortical plus white matter ROIs).
For each functional category, the percentage of DES-defined subcortical white matter positive sites that overlap with a given ROI is presented. For example, 28.4% of sites where alexia was elicited with direct electrical stimulation of the subcortical white matter overlapped with the JHU Atlas-defined inferior temporal gyrus, and 5.8% overlapped with the JHU Atlas-defined inferior temporal gyrus white matter. AG: angular gyrus; CG: cingulate gyrus; FG: fusiform gyrus; FOC: fronts-orbital cortex; MFG: middle frontal gyrus; MOG: middle occipital gyrus; MTG: middle temporal gyrus; IFG: inferior frontal gyrus; IOG: inferior occipital gyrus; ITG: inferior temporal gyrus; PreCG: pre-central gyrus; PostCG: post-central gyrus; SFG: superior frontal gyrus; SMG: supra marginal gyrus; SOG: superior occipital gyrus; SPL: superior parietal lobule; STG: superior temporal gyrus; WM: white matter.
| Left hemisphere | Right hemisphere | |
|---|---|---|
| Acoustic responses | STG (31%), STG WM (21.1%), MTG (2.9%) | STG (20.4%), MTG (14.1%), STG WM (5.5%), MTG WM (4.9%) |
| Reading | ITG (28.4%), FG (21.5%), MTG (8.2%), IOG (6.5%), ITG WM (5.8%), MTG WM (5.3%), FG WM (5.2%), IOG WM (3.4%) | ITG (4.3%), ITG WM (2.4%) |
| Anomia | STG (11.5%), MFG (8.1%), MFG WM (7.8%), AG (7.4%), AG WM (7%), MTG (6.9%), ITG (6.6%)STG WM (4.1%), IFG WM (3.3%), SMG (2.9%), insula (2.6%), lateral FOC (2.5%), ITG WM (2.3%), MTG WM (2%), IFG (1.9%), SMG WM (1.3%), lateral FOC WM (1.1%), FG (1%) | AG WM (3.8%), AG (1.8%), MTG WM (1%) |
| Comprehension | SPL (3.3%), STG (3.2%), insula (2.9%), SPL WM (2.6%), SMG WM (2.1%), MFG WM (1.7%), STG WM (1.2%) | MFG WM (9.7%), STG (7%), hippocampus (6.9%), MFG (6.7%), STG WM (6.6%), AG WM (6.6%), MTG WM (4.9%), AG (3.9%), insula (3.6%), ITG WM (2.7%), ITG (2%), PostCG (1.2%), SMFG (1.2%), MTG (1.1%) |
| Eye movement Control | MFG (23.4%), MFG WM (19.3%), SFG WM (4%), PreCG (3.8%), PreCG WM (3.6%), SFG (2.2%) | MFG (19.6%), MFG WM (9.5%), SFG (3.8%), SFG WM (1.3%) |
| Language and Motor Planning | CN (13.9%), SFG WM (6%), SFG (4.9%), MFG WM (3%), insula (2.9%), IFG (2.4%), lateral FOC WM (2.1%), IFG WM (1.9%), MFG (1.8%), Putamen (1.4%), lateral FOC (1.1%) | CN (1.3%) |
| Mentalizing | - | MFG WM (12.4%), IFG (9.9%), MFG (9.2%), SFG (8.8%), IFG WM (6.7%), SFG WM (6.5%), CG (3.7%), CN (3.3%), insula (1%) |
| Motor | PreCG WM (5.2%), SFG (4.6%), PreCG (4.5%), SFG WM (4.2%), putamen (2.4%), insula (2.3%), MFG (1.7%) | preCG WM (5.9%), SFG (5.2%), putamen (4.9%), SFG WM (4.6%), PreCG (4.3%), insula (4.2%), MFG (3.3%), MFG WM (2.4%), PostCG (2.1%), SLF (2.1%), PostCG WM (1.6%), IFG (1.2%), IFG WM (1%) |
| Motor Control | SFG WM (8.9%), SFG (7.5%), MFG WM (3.4%), MFG (3.1%), CG (1.7%), PostCG WM (1.4%), PostCG (1.3%), preCG (1.1%) | SFG (10.3%), SFG WM (6.9%), MFG (4.9%), CG (4.7%), IFG (4.6%), IFG WM (4.2%), insula (2.8%), MFG WM (2.5%), putamen (1.9%), precuneus (1.4%) |
| Phonological | ITG (10.3%), MTG (8.4%), MTG WM (7.9%), FG (6.3%), IFG WM (5.8%), STG (4.9%), SPL WM (3.6%), ITG WM (3.2%), IFG (2.9%), MFG (2.8%), STG WM (2.7%), AG WM (2.4%), MFG WM (2.4%), PostCG WM (2%), SS (2%), PreCG WM (1.9%), AG (1.9%), PostCG (1.9%), SPL (1.8%), SMG WM (1.5%), PreCG (1.5%), SMG (1.4%), insula (1.2%) | - |
| Semantic | MTG WM (7.7%), insula (6.9%), MTG (5.7%), STG (5.5%), hippocampus (4.9%), MFG WM (4.6%), ITG (4.6%), ITG (4.6%), FG (4.4%), ITG WM (4.6%), STG WM (3.9%), MFG 3.2%), IFG (3.1%), IFG WM (2.7%), putamen (2%), lateral FOC (2%), FG WM (1.7%), SFG WM (1.3%) | - |
| Somatosensory | SPL WM (6.2%), SPL (2.9%), PostCG WM (2.7%), precuneus (2.5%), PostCG (1.2%), preCG (1.2%), PreCG WM (1.1%) | SPL (8.6%), PostCG WM (8.3%), PostCG (8.1%), SPL WM (7.1%), SMG (6.7%), AG (4.6%), SMG (4.6%), insula (3%), pre-cuneus (2.4%), STG (2.2%), AG WM (2%), PreCG (1.7%) |
| Spatial perception | AG WM (6.7%), AG (6.2%) | SMG (17.1%), SMG WM (11.9%), AG (10.5%), AG WM (6.7%), STG (4.4%), SPL WM (4.2%), STG WM (3.3%), MFG WM (3.2%), PostCG WM (2.6%), SPL (1.9%), CG (1.6%), MTG (1.5%), PreCG WM (1.3%), MFG (1.3%) |
| Speech Output | IFG (11.4%), IFG WM (10.7%), PreCG (8%), PreCG WM (7.7%), MFG (5.2%), STG (5.1%), insula (4.1%), MFG WM (2.5%), STG WM (1.7%) | PreCG WM (6.1%), PReCG (6%), MFG (4.1%), IFG (3.8%), insula (3.6%), MFG WM (3.3%), IFG WM (3.1%), putamen (1.6%) |
| Speech Articulation | SMG WM (10.6%), SMG (10.5%), PostCG (6.1%), PreCG WM (6.1%), PostCG WM (5.2%), PreCG (5.1%), IFG (4.1%), MFG (4%), IFG WM (3.6%), MFG WM (3.2%), STG (3.1%), AG WM (2.9%), AG (2.8%), insula (2.5%), SFG WM (1.2%) | SMG (2.6%), SMG WM (2.4%), IFG (2.3%), MFG (2.2%), SFG WM (1.6%), MFG WM (1.3%) |
| Visual | FG (8.6%), IOG WM (3.1%), FG WM (2.9%), MOG WM (1.9%), IOG (1.5%) | AG WM (9%), AG (5.4%), IOG (4.1%), MTG WM (3.8%), MOG WM (3.3%), Hippocampus (3.1%), FG (2.7%), IOG WM (2.3%), SPL WM (2%), SOG WM (1.8%), MOG (1.6%), MTG (1.5%), ITG (1.5%), FG WM (1.2%), STG WM (1%), SMG WM (1%) |