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. 2020 May 8;12:3223–3235. doi: 10.2147/CMAR.S237582

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© 2020 Dai et al.

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WDR5 regulates the expression level of ZEB1. (A) Heat map of genes differentially expressed after knockdown of WDR5 in SW 1783 cells as measured by microarray. (B) Gene ontology analysis for genes regulated by WDR5’s knockdown in SW 1783 cells. (C) Effects of WDR5’s knockdown on the expression of ZEB1 were measured by Western blot. (D) Effects of WDR5’s knockdown on the expression of ZEB1 were measured by quantitative RT-PCR. (E) The expression of ZEB1 and WDR5 are relevant in glioma tissues. All experiments were repeated at least three times, and representative data are shown. **P<0.01 compared to mock is based on the Student’s t-test. Error bars, SD.

Abbreviations: ZEB1, Zinc finger E-box binding homeobox 1; WDR5, WD repeat domain 5; RT-PCR, Real time- Polymerase Chain Reaction.