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. 2020 May 8;12:3223–3235. doi: 10.2147/CMAR.S237582

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© 2020 Dai et al.

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ZEB1 is a mediator of WDR5-induced malignant behaviors in glioma cells. (A) The silencing of ZEB1 was measured by Western blot in U 373-WDR5 cells. (B) The proliferation was measured by MTT assay in U 373-WDR5 cells after knockdown of ZEB1. (C-F) ZEB1’s knockdown and its control cells were subjected to transwell migration (C and D) and matrigel invasion (E and F) assays. (G) Expression of E-cadherin and N-cadherin were measured by Western blot. All experiments were repeated at least three times, and representative data are shown. **, ^##P< 0.01 is based on One way ANOVA. Error bars, SD.

Abbreviations: ZEB1, Zinc finger E-box binding homeobox 1; WDR5, WD repeat domain 5.