Table 3.
Up- or down-regulated genes in Ahr KO mice.
| Genbank ID |
Common name |
Relative mRNA expression |
||
|---|---|---|---|---|
| Gene name | 7 w | 60 w | ||
| Up regulation (23 genes) | ||||
| Cancer | ||||
| Rab38, member of RAS oncogene family | NM_028238 | Rab38 | 2.1 | 4.3 |
| Vav2 oncogene | NM_009500 | Vav2 | 2.1 | 2.2 |
| Cell cycle regulator | ||||
| Cyclin B2 | NM_007630 | Ccnb2 | 3.8 | 2.1 |
| Enzyme | ||||
| Aldo-keto reductase family 1, member B7 | NM_009731 | Akr1b7 | 2.0 | 2.6 |
| Arylacetamide deacetylase (esterase) | NM_023383 | Aadac | 2.5 | 2.0 |
| Asparagine synthetase | U38940 | Asns | 6.5 | 5.0 |
| Cis-retinol/3alpha hydroxysterol short-chain dehydrogenase-like | BC018263 | CRAD-L | 3.2 | 3.1 |
| Cytochrome c oxidase, subunit VIIa 1 | NM_009944 | Cox7a1 | 2.8 | 2.1 |
| Cytochrome P450, family 4, subfamily a, polypeptide 14 | NM_007822 | Cyp4a14 | 3.6 | 4.1 |
| Cytochrome P450, family 17, subfamily a, polypeptide 1 | NM_007809 | Cyp17a1 | 12.5 | 2.1 |
| Glutaredoxin 2 (thioltransferase) | NM_023505 | Glrx2 | 2.3 | 2.2 |
| Hydroxysteroid (17-beta) dehydrogenase 9 | NM_013786 | Hsd17b9 | 3.0 | 3.5 |
| Lipoprotein lipase | NM_008509 | Lpl | 14.0 | 5.5 |
| Methylmalonyl-Coenzyme A mutase | NM_008650 | Mut | 23.6 | 9.8 |
| RIKEN cDNA 2310016A09 gene | BC024580 | RIKEN | 4.7 | 2.7 |
| Motor | ||||
| Dynein, axonemal, intermediate chain 1 | AK004387 | Dnaic1 | 4.1 | 8.2 |
| Signal transducer | ||||
| Insulin-like growth factor binding protein 1 | NM_008341 | Igfbp1 | 3.2 | 4.8 |
| Structural protein | ||||
| CD59a antigen | NM_007652 | Cd59a | 8.4 | 3.7 |
| Collectin sub-family member 11 | AK003121 | Colec11 | 2.2 | 2.3 |
| Olfactory receptor 65 (Olfr65) | NM_013617 | Olfr65 | 2.3 | 2.5 |
| Transport | ||||
| Fatty acid binding protein 5, epidermal | NM_010634 | Fabp5 | 2.3 | 2.7 |
| Solute carrier organic anion transporter family, member 1a4 | NM_030687 | Slco1a4 | 2.9 | 2.3 |
| Others | ||||
| Ubiquitin-associated protein 1 | NM_023305 | Ubap1 | 5.8 | 3.3 |
| Down regulation (20 genes) | ||||
| Enzyme | ||||
| Betaine-homocysteine methyltransferase | NM_016668 | Bhmt | 0.48 | 0.49 |
| Cytochrome P450, family 1, subfamily a, polypeptide 2 | NM_009993 | Cyp1a2 | 0.30 | 0.36 |
| Dopachrome tautomerase | NM_010024 | Dct | 0.26 | 0.32 |
| Glutathione peroxidase 6 | NM_145451 | Gpx6 | 0.45 | 0.37 |
| Interferon gamma-induced GTPase | NM_018738 | Igtp | 0.28 | 0.27 |
| Isovaleryl coenzyme A dehydrogenase | NM_019826 | Ivd | 0.16 | 0.18 |
| NADH dehydrogenase (ubiquinone) Fe-S protein 5 | NM_134104 | Ndufs5 | 0.02 | 0.01 |
| Sulfotransferase family 5A, member 1 | NM_020564 | Sult5a1 | 0.30 | 0.29 |
| UDP glucuronosyltransferase 1 family, polypeptide A6 | U16818 | Ugt1a6 | 0.38 | 0.48 |
| Expressed sequence AI586015 | NM_019992 | AI586015 | 0.26 | 0.42 |
| RIKEN cDNA E430034L04 gene | NM_011816 | RIKEN | 0.43 | 0.42 |
| Immunity | ||||
| Plasminogen | NM_008877 | Plg | 0.49 | 0.40 |
| Signal transducer | ||||
| Transforming growth factor beta 1 induced transcript 4 | NM_009366 | Tgfb1i4 | 0.23 | 0.46 |
| Structural protein | ||||
| Growth arrest specific 5 | NM_013525 | Gas5 | 0.27 | 0.46 |
| Prion protein | NM_011170 | Prnp | 0.48 | 0.50 |
| Transport | ||||
| Amiloride-sensitive cation channel 5, intestinal | NM_021370 | Accn5 | 0.12 | 0.23 |
| Aquaporin 8 | NM_007474 | Aqp8 | 0.46 | 0.39 |
| Solute carrier family 2 (facilitated glucose transporter), member 2 | NM_031197 | Slc2a2 | 0.47 | 0.26 |
| Solute carrier family 22 (organic anion transporter), member 7 | NM_144856 | Slc22a7 | 0.35 | 0.47 |
| Sorting nexin 1 | NM_019727 | Snx1 | 0.42 | 0.45 |
Up-regulated and down-regulated genes showed more than 200% and less than 50% expressions, respectively, compared with those in wild-type mice at the same weeks old.
Categories of first occurrence in Table 2 are listed.