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. 2020 May 8;12:3247–3255. doi: 10.2147/CMAR.S253565

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© 2020 Huang et al.

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Enhanced cytotoxicity of CAR⁺NK-92 cells with NK-cell costimulatory domain. (A) Semi-quantification of residual target cells at indicated E/T ratio. The data are presented as the mean ± s.d. of triplicate wells. *p < 0.05, **p < 0.01, Z or CD28.Z group vs DNAM1.Z or 2B4.Z group; ^#p < 0.05, ^##p < 0.05, DNAM1.Z or 2B4.Z group vs DNAM1.2B4.Z group. (B) Detection of released IFN-γ and TNF-α by ELISA after a 24-h coculture at an E/T of 1/1. The data are presented as the mean ± s.d. of triplicate wells. Unpaired two-tailed t-test: ***p < 0.001, Z or CD28.Z group vs DNAM1.Z or 2B4.Z group; #p < 0.05, DNAM1.Z or 2B4.Z group vs DNAM1.2B4.Z group.