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Roundabout guidance receptor 4 (Robo4) modulates endothelial function through inhibition of pro-angiogenic vascular endothelial growth factor (VEGF) signaling. When activated by its endogenous ligand slit homolog 2 (Slit2), Robo4, an endothelial specific Robo isoform, inhibits pro-angiogenic VEGF signaling through ADP ribosylation factor 6 (Arf6) and Rac and may reduce nitric oxide mediated vasodilation.
