Figure 5.

Fasted blood glucose (A), blood glucose during a glucose tolerance test (GTT) (B) and area under the curve for glucose during the GTT (C) xin normal chow (NC) and high fat diet (HF) fed wildtype (WT) and roundabout receptor 4 (Robo4) knockout (KO) mice. WT and KO mice were fed either NC or HF (40% fat by kcal) for 8–10 weeks before testing. Mice were fasted for 4 hr and blood was collected via a tail nick. Glucose (2g/kg) was administered intraperitoneally and blood glucose was measured at 15, 30,45, 60 and 90 after injection. †denotes difference from HF fed of same genotype, Data are means ± SEM, p≤0.05