Figure 3.

A Distinct Trajectory for Megakaryocyte Differentiation Is Dramatically Expanded in Myelofibrosis

(A–D) Force-directed graphs (FDGs) for aggregate of all control + myelofibrosis cells (A), myelofibrosis only (B), control only (C), and control + down-sampled myelofibrosis dataset (D). In (D), the left graph shows lineage signature gene score and in the right graph cells are colored according to the donor type (healthy donors, blue; myelofibrosis, red). Gene expression trajectories are visualized by superimposing the expression scores of lineage signature gene sets on FDG. Grey cells represent uncommitted HSPCs or cells with expression of more than 1 lineage signature. See also Figures S2 and S3 and Table S5.