Table 1.

Kyoto Encyclopedia of Genes and Genomes pathways significantly enriched in CTNS^KO iPSCs (cutoff P<1×10⁻⁶)

Entry	Name	Class	P Value	numDEInCat	numInCat
hsa03010	Ribosome; Homo sapiens (human)	Genetic information processing; translation	p<0.001	81	87
hsa05016	Huntington disease; H. sapiens (human)	Human diseases; neurodegenerative diseases	p<0.001	134	182
hsa05012	Parkinson disease; H. sapiens (human)	Human diseases; neurodegenerative diseases	p<0.001	93	129
hsa04110	Cell cycle; H. sapiens (human)	Cellular processes; cell growth and death	p<0.001	105	124
hsa03040	Spliceosome; H. sapiens (human)	Genetic information processing; transcription	p<0.001	101	127
hsa03008	Ribosome biogenesis in eukaryotes; H. sapiens (human)	Genetic information processing; transcription	p<0.001	66	76
hsa00190	Oxidative phosphorylation; H. sapiens (human)	Metabolism; energy metabolism	p<0.001	90	131
hsa04141	Protein processing in endoplasmic reticulum; H. sapiens (human)	Genetic information processing; folding, sorting, and degradation	p<0.001	130	166
hsa04120	Ubiquitin-mediated proteolysis; H. sapiens (human)	Genetic information processing; folding, sorting, and degradation	p<0.001	111	135
hsa03013	RNA transport; H. sapiens (human)	Genetic information processing; translation	p<0.001	116	150
hsa05010	Alzheimer disease; H. sapiens (human)	Human diseases; neurodegenerative diseases	p<0.001	116	166
hsa03050	Proteasome; H. sapiens (human)	Genetic information processing; folding sorting, and degradation	p<0.001	37	44