Table 5.

Discrimination and calibration of CKD progression from biomarker values in the highest quartile

Model	Uno C-Statistic	Difference in C-Statistic (95% CI)	IDI (95% CI)	Continuous NRI (95% CI)
Clinical model (as reference)	0.76 (0.73 to 0.80)
Clinical model plus biomarker
KIM-1	0.78 (0.75 to 0.81)	0.02 (0.01 to 0.03)	0.05 (−0.01 to 0.10)	0.27 (−0.25 to 0.42)
MCP-1	0.76 (0.73 to 0.80)	0 (−0.01 to 0.01)	0.01 (−0.02 to 0.05)	0.07 (−0.28 to 0.41)
TNFR-1	0.77 (0.74 to 0.80)	0.01 (−0.01 to 0.02)	0 (−0.04 to 0.04)	−0.05 (−0.37 to 0.40)
TNFR-2	0.76 (0.73 to 0.80)	0 (−0.01 to 0.01)	0 (−0.03 to 0.04)	0.10 (−0.24 to 0.42)
suPAR	0.76 (0.73 to 0.80)	0 (−0.01 to 0.01)	0 (−0.03 to 0.02)	−0.03 (−0.35 to 0.37)
YKL-40	0.76 (0.73 to 0.80)	0 (−0.01 to 0.01)	0 (−0.03 to 0.01)	−0.17 (−0.47 to 0.34)
Clinical model plus biomarker combinations
Plus KIM-1 and TNFR-1	0.79 (0.75 to 0.82)	0.03 (0.01 to 0.04)	0.04 (−0.02 to 0.10)	0.13 (−0.24 to 0.48)
Plus TNFR-2	0.78 (0.75 to 0.82)	0.02 (0.01 to 0.04)	0.05 (−0.02 to 0.14)	0.23 (−0.16 to 0.53)
Plus MCP-1	0.79 (0.75 to 0.82)	0.03 (0.01 to 0.04)	0.05 (0 to 0.14)	0.28 (−0.15 to 0.50)
Plus suPAR	0.79 (0.75 to 0.82)	0.03 (0.01 to 0.04)	0.05 (−0.02 to 0.13)	0.26 (−0.21 to 0.50)
Plus YKL-40	0.79 (0.75 to 0.82)	0.03 (0.01 to 0.04)	0.04 (−0.03 to 0.10)	0.14 (−0.27 to 0.48)
Clinical with all biomarkers	0.79 (0.75 to 0.82)	0.03 (0.01 to 0.04)	0.07 (0 to 0.19)	0.37 (−0.19 to 0.54)