Table 2.
A clinical score to stratify risk of postnephrectomy eGFR <45 ml/min per 1.73 m2
Variable | Coefficient | Points | Score | Risk Stratum | Predicted Probabilitya | Observed Absolute Riskb | Relative Risk (95% CI)c |
---|---|---|---|---|---|---|---|
Age, yr | 0 | Negligible | 0.8% (0.2% to 1.6%) | <2% | 0.05 (0.00 to 0.35) | ||
<65 | 0.00 | 0 | 1 | ||||
≥65 | 0.66 | 1 | 2 | ||||
Diabetes mellitus | 3 | ||||||
No | 0.00 | 0 | |||||
Yes | 0.66 | 1 | 4 | Low | 6% (3% to 10%) | 3%–14% | 1.00 |
Preoperative eGFRd | 5 | ||||||
60–69 | 3.16 | 5 | 6 | ||||
70–79 | 2.41 | 4 | |||||
80–89 | 1.76 | 3 | 7 | Moderate | 23% (17% to 29%) | 21%–26% | 2.71 (1.51 to 4.91) |
≥90 | 0.00 | 0 | 8 | ||||
Management plan | |||||||
Partial nephrectomy | 0.00 | 0 | 9 | High | 51% (43% to 59%) | 46%–69% | 5.93 (3.30 to 10.64) |
Radical nephrectomy | 1.79 | 3 | 10 |
Logistic coefficients are from model 3 (Table 1). To derive the points system, each coefficient was divided by the lowest value (0.66) and rounded to the nearest integer. 95% CI, 95% confidence interval.
Mean (range) of predicted probability of the primary outcome for scores contained within respective strata.
Range of absolute risk of the outcome within each stratum across all four cohorts (excluding living kidney donor analysis).
Relative risk was calculated by comparing risk strata using a univariable log-binomial regression in the derivation cohort (with reference to the “low-risk” stratum).
eGFR in ml/min per 1.73 m2.