Figure 3.
Acute effects of radiation (2 days after RT) on FUS-induced BBB opening (n = 4). (A) Representative brain permeability map in the striatum. (B) The permeability (Ktrans) and (C) calculated gadolinium concentration showed an increased trend on the RT side, although there are no statistically significant differences. (D) Representative vascular staining (lectin) images from sections with and without radiation treatment. (E) Measurements of mean vessel area showed no significant difference. (F) Measurements of blood vessel density indicated a significant decrease on the hemisphere received both radiation and FUS (p = 0.0032). FUS, focused ultrasound; RT, radiation therapy.