Table.

Effectiveness, safety, and cost of TDF/FTC and TAF/FTC for HIV preexposure prophylaxis

	TDF/FTC	TAF/FTC
Effectiveness*
MSM and transgender women	~99%	~99%
Heterosexual women and men	~99%	Unknown
People who inject drugs	74-84%	Unknown
Changes in safety parameters at 48 weeks(4, 9)
Estimated glomerular filtration rate, mean (mL/min)	−2.0	+2.0
Hip bone mineral density, mean (%)	−1.0	+0.2
Fasting low-density lipoprotein, median (mg/dL)	−6.5	+1.0
Body weight, mean (kg)	0	+1.1
Cost
Average wholesale price per month	$2,110	$2,110
Generic version available	2020	2022 to 2025

TDF/FTC, tenofovir disoproxil fumarate with emtricitabine; TAF/FTC, tenofovir alafenamide with emtricitabine.

^*Effectiveness estimates for TDF/FTC are from the Centers for Disease Control and Prevention (https://www.cdc.gov/hiv/risk/estimates/preventionstrategies.html).