Table 4.

Number needed to treat with aspirin during 5 years to cause one major bleeding event.

	Observed events at 5 years		Aspirin (assuming 42% RRI)
	Number	Incidence (%)	Incidence (%)	ARI (%)	NNH
Overall	23	0.67	0.95	0.28	355
By CAC Score
CAC=0	9	0.42	0.60	0.18	567
CAC 1–99	12	1.43	2.03	0.60	167
CAC≥100	2	0.46	0.65	0.19	518
CAC≥400	0	0.00	–*	–*	–*
By ASCVD Risk
ASCVD Risk <5%	5	0.30	0.43	0.13	794
ASCVD Risk 5–20%	16	1.04	1.48	0.44	229
ASCVD Risk >20%	2	0.93	1.32	0.39	256

^*Could not be computed.

Results presented as number or %. Follow-up was censored at 5 years. The 10-year ASCVD risk was estimated using the Pooled Cohort Equations.

Abbreviations: ARI = Absolute Risk Increase; ASCVD = atherosclerotic cardiovascular disease events; CAC = coronary artery calcium; NNH = number needed to harm; RRI = relative risk increase