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Effects of racemic α-PVP and its enantiomers in comparison to cocaine on uptake at DAT (a), NET (b) and SERT (c) in rat brain synaptosomes. Synaptosomes were incubated with different concentrations of α-PVP or its enantiomers or cocaine in the presence of 5 nM[3H]dopamine for DAT, 10 nM [3H]norepinephrine for NET or 5 nM [3H]5-HT for SERT. Data are percentage of [3H]neurotransmitter uptake expressed as mean ± SEM for n = 3 experiments performed in triplicate.
