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Effects of α-PVP and its enantiomers in comparison to cocaine on transporter-mediated inhibition of [3H]transmitter uptake in rat brain synaptosomesa
| R,S-α-PVP | S-α-PVP | R-α-PVP | Cocaine | |
|---|---|---|---|---|
| DAT | 15 ± 1.0 | 7 ± 0.5 | 307 ± 41.8 | 256 ± 12.5 |
| NET | 19 ± 2.4 | 10 ± 1.0 | 181 ± 15.3 | 247 ± 20.7 |
| SERT | >10,000 | >10,000 | >10,000 | 318 ± 7.2 |
Data are IC50 values (nM) expressed as mean ± SEM for n = 3 separate experiments performed in triplicate.
