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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: FEBS Lett. 2020 Feb 6;594(9):1389–1402. doi: 10.1002/1873-3468.13740

Figure 7. Schematic representation of the effects of MAG and cAMP on Rap1 activation and neurite outgrowth.

Figure 7.

In the presence of MAG, Rap1GAP1 levels are increased, which leads to inactivation of Rap1 and inhibition of neurite outgrowth. Conversely, when intracellular cAMP is elevated, Rap1GAP1 levels are reduced and this leads to an increase in Rap1 activity, which facilitates neurite outgrowth. Activation of EPAC can also increase neurite outgrowth, but only in response to priming with agents such as 8-CPT.