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. 2020 Mar 24;122(10):1525–1534. doi: 10.1038/s41416-020-0813-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a The effect of pembrolizumab on the expression of cytolytic markers (GZMB, CD107a and PRF1) in CD103^-CD8⁺ T cells and CD103^-CD8⁺ T cells from gastric cancer tissue samples (n = 12). b The effect of pembrolizumab on the expression of effector cytokines (IFN-γ, TNF-α and IL-2) in CD103^-CD8⁺ T cells and CD103^-CD8⁺ T cells from gastric cancer tissue samples (n = 12). c The effect of pembrolizumab on the proliferation capacity of CD103^-CD8⁺ T cells and CD103^-CD8⁺ T cells from gastric cancer tissue samples (n = 12). d Association of CD103⁺CD8⁺ T cell frequencies with the change in apoptotic (left panel) and proliferative (right panel) tumour cells induced by pembrolizumab in gastric cancer tissue samples (n = 12). Bar plots show the mean ± SD; GZMB granzyme B, IFN-γ interferon gamma, PRF1 perforin, IL-2 interleukin-2. Bar plots show the mean ± SD. Significance was assessed by paired t-test. n.s. not significant.