Table 4.

Predicted median time in days to reach factor VIII threshold levels of 1, 3, and 5 IU/dL after a single BAY 94-9027 dose stratified by patient age

FVIII threshold (IU/dL)	BAY 94-9027 dose (IU/kg)	Median time (5th–95th percentile) [days]
		Age 12 to < 18 years (n = 12)	Age ≥ 18 years (n = 133)
1	25	4.3 (2.8–6.0)	4.4 (2.8–6.7)
	35	4.6 (3.0–6.5)	4.8 (3.1–7.3)
	45	5.0 (3.2–6.8)	5.0 (3.2–7.7)
	50	5.0 (3.2–7.0)	5.1 (3.3–7.8)
	60	5.2 (3.4–7.3)	5.3 (3.4–8.1)
3	25	3.1 (2.0–4.4)	3.3 (2.1–5.0)
	35	3.5 (2.2–4.9)	3.6 (2.3–5.5)
	45	3.7 (2.4–5.2)	3.9 (2.5–5.9)
	50	3.8 (2.5–5.4)	4.0 (2.5–6.1)
	60	4.0 (2.6–5.7)	4.2 (2.7–6.4)
5	25	2.6 (1.7–3.6)	2.7 (1.7–4.2)
	35	2.9 (1.9–4.1)	3.1 (1.9–4.7)
	45	3.2 (2.1–4.5)	3.4 (2.1–5.1)
	50	3.3 (2.1–4.6)	3.5 (2.2–5.3)
	60	3.5 (2.3–4.9)	3.7 (2.3–5.6)

FVIII factor VIII