Table 5.

Simulation results for percentage of patients with factor VIII levels above threshold at steady state

Dosing frequency by age group	BAY 94-9027 dose (IU/kg)	Patients above threshold FVIII level (%)
		≥ 1 IU/dL	≥ 3 IU/dL	≥ 5 IU/dL
Once weekly
12 to < 18 years	60	11.3	1.4	0.6
≥ 18 years	60	18.6	5.5	2.9
Twice weekly
12 to < 18 years	25	60.1	19.8	7.6
	30	66.9	25.5	10.4
	40	74.9	36.8	18.6
≥ 18 years	25	60.2	27.6	13.8
	30	63.9	33.0	18.1
	40	70.4	41.2	27.0
Every 5 days
12 to < 18 years	45	45.6	13.3	4.5
	50	48.5	15.3	6.1
	60	55.3	20.3	8.8
≥ 18 years	45	47.9	20.8	10.0
	50	51.8	23.4	12.4
	60	56.2	27.6	15.5

FVIII factor VIII