| A robust population pharmacokinetics (popPK) model was derived for BAY 94-9027 using data from three BAY 94-9027 clinical trials, including 198 patients with severe hemophilia A. |
| BAY 94-9027 pharmacokinetics were adequately described using a one-compartment model in which lean body weight explained much of the inter-patient variability seen in clearance and volume of distribution of the central compartment. |
| The popPK model can be used to accurately determine BAY 94-9027 pharmacokinetic profiles for individual patients using sparse blood sampling. |
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